Azithromycin and asthma

Discussion in 'Prescription Online' started by marian, 03-Sep-2019.

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    Azithromycin and asthma


    Background Patients with severe asthma are at increased risk of exacerbations and lower respiratory tract infections (LRTI). Severe asthma is heterogeneous, encompassing eosinophilic and non-eosinophilic (mainly neutrophilic) phenotypes. Patients with neutropilic airway diseases may benefit from macrolides. Methods We performed a randomised double-blind placebo-controlled trial in subjects with exacerbation-prone severe asthma. Subjects received low-dose azithromycin (n=55) or placebo (n=54) as add-on treatment to combination therapy of inhaled corticosteroids and long-acting β agonists for 6 months. The primary outcome was the rate of severe exacerbations and LRTI requiring treatment with antibiotics during the 26-week treatment phase. Secondary efficacy outcomes included lung function and scores on the Asthma Control Questionnaire (ACQ) and Asthma Quality of Life Questionnaire (AQLQ). Das Antibiotikum Azithromycin kann Asthma-Symptome positiv beeinflussen. Doch kann es auch akuten Verschlechterungen, sogenannten Exazerbationen, entgegenwirken? Dieser Frage ist nun ein australisches Forscher-Team nachgegangen. Anhaltende Asthma-Anfälle beeinflussen die Lebensqualität von Betroffenen stark. Und auch wer regelmäßig Medikamente wie Kortikosteroide oder Bronchodilatatoren einnimmt, kann immer wieder akute Verschlechterungen der Krankheit (Exazerbationen) erleben. Forscher aus Australien haben diesbezüglich nun das Antibiotikum Azithromycin unter die Lupe genommen, da frühere Studien bereits Hinweise geliefert haben, dass das Medikament Asthma-Symptome positiv beeinflussen kann. In ihrer Studie, die sie in der Fachzeitschrift „The Lancet“ veröffentlichten, konnten die Wissenschaftler nun zeigen, dass Azithromycin akute Verschlechterungen bei anhaltendem unkontrolliertem Asthma verhindern kann. Für ihre Studie untersuchten die Forscher 420 erwachsene Personen, die alle an anhaltendem Asthma litten, welches trotz Behandlung mit Medikamenten nicht kontrollierbar war.

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    Jan 18, 2017. Adding azithromycin to usual treatment for asthma exacerbations in adults did not improve asthma symptoms or speed their resolution. Methods We performed a randomised double-blind placebo-controlled trial in subjects with exacerbation-prone severe asthma. Subjects received low-dose. The goal of our trial, AZithroMycin-Asthma Trial In Community Settings AZMATICS, was to investigate whether azithromycin has value for patients with.

    The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Azithromycin has been used successfully in other chronic lung diseases, including cystic fibrosis. Listing a study does not mean it has been evaluated by the U. Despite limited clinical evidence, some pediatricians use azithromycin in children hospitalized with asthma, citing either treatment of atypical pathogens or its proposed anti-inflammatory properties. Asthma is a chronic lung condition in children, and often requires hospitalization for acute exacerbations. This study proposes a clinical trial to determine if azithromycin will shorten length of stay in children hospitalized with acute asthma exacerbations. Asthma is a chronic lung condition that accounts for over 130,000 pediatric hospitalizations nationally at a cost of almost 1.4 billion dollars. Atypical pathogens have been implicated both in initiating asthma and triggering acute asthma exacerbations. Azithromycin, a macrolide antibiotic, is known to have antibacterial activity against atypical pathogens and gram positive bacteria. Kann das Antibiotikum Azithromycin akute Verschlechterungen von anhaltendem unkontrolliertem Asthma verhindern? Und wie wirkt sich die Antibiotika-Therapie auf die Lebensqualität der Betroffenen aus? Diese Fragen untersuchte ein australisches Forscher-Team in einer Studie, die in der Fachzeitschrift 'The Lancet' veröffentlicht wurde. Anhaltendes unkontrolliertes Asthma hat einen großen Einfluss auf das Leben von Betroffenen. Denn obwohl sie regelmäßig Medikamente wie inhalative Kortikosteroide und langwirksame Bronchodilatatoren einnehmen, kann es immer wieder zu akuten Verschlechterungen der Krankheit (Exazerbationen) kommen. Die wiederkehrenden Exazerbationen und die damit verbundenen Arztbesuche oder auch Krankenhausaufenthalte beeinträchtigen die Lebensqualität der Betroffenen sehr. Forscherinnen und Forscher sind daher ständig auf der Suche nach weiteren Therapieoptionen.

    Azithromycin and asthma

    Azithromycin kann Asthma-Exazerbationen verhindern., Azithromycin for prevention of exacerbations in severe asthma.

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    Lancet. 2017 Aug 12;39010095659-668. doi 10.1016/S0140-67361731281- 3. Epub 2017 Jul 4. Effect of azithromycin on asthma exacerbations and quality. In other words This dosage was 1000 mg of azithromycin once a week, for 9 weeks. After the first dose I still had asthma and didn't seem to be that much better. Aug 1, 2017. Azithromycin significantly reduced exacerbations and improved health-related quality of life QoL in adults with uncontrolled asthma, according.

     
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