Phosphodiesterases (PDEs) are a superfamily of enzymes. This superfamily is further classified into 11 families, PDE1 - PDE11, on the basis of regulatory properties, amino acid sequences, substrate specificities, pharmacological properties and tissue distribution. Their function is to degrade intracellular second messengers such as cyclic adenine monophosphate (c AMP) and cyclic guanosine monophosphate (c GMP) which leads to several biological processes like effect on intracellular calcium level by the Ca The human genome contains at least 21 genes involved in determining the intracellular levels of c AMP and c GMP by the expression of phosphodiesterase proteins or PDE’s. These PDE’s are grouped into at least 11 functional subfamiles, named PDE1-PDE11. PDEs are enzymes that hydrolyze cyclic adenosine 3,5-monophosphate (c AMP) and cyclic guanosine 3,5-monophospahate (c GMP), which are intracellular second messengers, into AMP and GMP. 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