Valaciclovir, also spelled valacyclovir, is an antiviral drug used in the management of herpes simplex, herpes zoster (shingles), and herpes B. It is a prodrug, which is converted to aciclovir in a persons body. Common adverse drug reactions (≥1% of patients) associated with valaciclovir therapy are the same as for aciclovir, its active metabolite, and include: nausea, vomiting, diarrhea and headache. Infrequent adverse effects (0.1–1% of patients) include: agitation, vertigo, confusion, dizziness, edema, arthralgia, sore throat, constipation, abdominal pain, rash, weakness and/or renal impairment. Rare adverse effects ( Valaciclovir belongs to a family of molecules first described and patented by Paolo Cornaglia Ferraris in 1982 (patents EP0077460 A2, CA1258149A1, DE3273785D1, EP0077460A3, EP0077460B1, US4567182). Valaciclovir is a prodrug, an esterified version of aciclovir that has greater oral bioavailability (about 55%) than aciclovir (10–20%). It is converted by esterases to the active drug aciclovir, as well as the amino acid valine, via hepatic first-pass metabolism. However, it is well documented that valtrex and acyclovir perform very similarly. Valtrex is actually converted into acyclovir by the liver, so essentially, the two drugs act the same way in the body to suppress the virus. If acyclovir improves your quality of life, I would stick with it and explain the similarities to your partner - they are well documented and I expect you can find information in scholarly journals that supports the suppressive activity of acyclovir. Valtrex is the dominant brand name, valacylcovir the generic name. (Probably not harmful, but not recommended.) You get maximum effectiveness against oral herpes with the 2 g (2000 mg) dose taken twice a day apart; higher, more frequent, or more prolonged treatment will make no difference. 2) You are typical in not having an identifed trigger of your outbreaks. it is design to suppress outbreak's ..the confusion is the volume of medication..400mg vs 200mg 3x for 7days Valtrex..2x a day for 7-10 day's ..explaining on directions is wrong in fact and why it is used .... I don't know..what it means is (this way of= taking it is design to take when you have a outbreak.if i have a out break... Boom...( I take it this way for 7 to ten day's to suppress the current outbreak).what about the gray area's. Viagra means Sildenafil same as viagra Amoxicillin price australia Can i buy viagra in sweden Acyclovir vs Valacyclovir for genital herpes, herpes zoster Valacyclovir vs Famciclovir All three of these oral antiviral drugs can be taken either episodically - when a person has an outbreak or feels one coming on, or suppressively - daily to help prevent the recurrence of outbreaks. The valacyclovir vs acyclovir debate started since then and it still remains a matter of research interest as to which drug you can use to cope with herpes better. Valacyclovir advantages Valacyclovir has a number of key advantages over other similar antiviral medications. Oral valacyclovir is better absorbed than oral acyclovir, increasing acyclovir bioavailability three- to fivefold. This provides the opportunity to explore whether high systemic acyclovir concentrations are effective in the treatment of cold sores herpes labialis. © 2005, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication. Vectavir is a brand name for penciclovir, an anti-herpes cream. Zovirax is a brand name for acyclovir, an anti-herpes drug that is available as a pill or a cream. In general, pills are much more effective for herpes than creams. Read more Vectavir (penciclovir) is a cream for herpes. Zovirax (acyclovir) is available both as a cream and pills to be taken by mouth. Neither cream works very well; if herpes treatment is needed, pills are always best. Some experts feel the newer agents and especially valcyclovir are better, but each can help. In other words, Vectavir and Zovirax creams are both poor treatments, but Zovirax pills usually are very effective. The choice depends on several factors - how often someone wants to or can take the med, for example. Read more I'm assuming you're talking about oral Valtrex (valacyclovir) and zovirax (not zovirax cream). The main issue is usually cost and whether one or the other is covered by insurance. Both are effective, but Valtrex (valacyclovir) is more convenient, because it doesn't have to be taken as frequently. Valacyclovir vs acyclovir Comparison of the Efficacy of Valacyclovir vs Acyclovir., Which Herpes Medicine is More Effective - Valacyclovir or. Valtrex how supplied Valacyclovir oral tablet is a prescription medication used to treat or prevent infections caused by the herpes simplex virus. These include cold sores, genital herpes, chickenpox, and shingles. Valacyclovir Side Effects, Dosage, Uses, and More. High-Dose, Short-Duration, Early Valacyclovir Therapy for.. Acyclovir vs Valacyclovir Difference Between Acyclovir and.. In the war between valacyclovir vs. acyclovir vs. famciclovir, the truth is, there is no “best” herpes medication. All three of the drugs are safe and proven to be effective as treatments for HSV-1, HSV-2, shingles and other forms of the herpes virus. Valacyclovir is the valyl ester of the antiviral drug acyclovir. Acting as an oral prodrug, valacyclovir is converted in vivo to acyclovir. Acyclovir, a nucleoside analog, is phosphorylated by virally-encoded thymidine kinase and subsequently by cellular enzymes, yielding acyclovir triphosphate, which competitively inhibits viral DNA polymerase. I believe though I could be wrong valacyclovir is the only drug that is approved by the FDA for suppressive therapy, because it's the only drug that has had an FDA registered clinical trial performed for this purpose. However, it is well documented that valtrex and acyclovir perform very similarly.