A study released today sends out a strongly worded warning about risks of kidney, liver, and other organ damage from the most popular weight drugs on the market. According to a University of Rhode Island study funded by the National Institutes of Health (NIH), orlistat, which goes by the prescription brand name Xenical and the over-the-counter name Alli, can cause "severe toxicity" to major internal organs. The research results obtained by pharmacology professor Bingfan Yan were worrying enough that he immediately reported the results to the FDA, which approved orlistat in 1999. Liver and kidney damage are serious enough, but Yan's team also reported another finding, just as concerning, that orlistat's metabolic action reduces the effectiveness of many medications, including life-saving cancer treatments. In fact, the researchers reported that cancer cells multiplied faster under the influence of orlistat. Orlistat also boosts the anti-clotting effects of aspirin, raising the risk of bleeding both internal and external. Yan and his team found that orlistat - even at low doses - limits the function of a key enzyme called carboxylesterase-2, which has an important role in detoxifying the liver, kidneys, and entire gastrointestinal tract. A few weeks ago, a middle-age patient who has been taking orlistat regularly for weight loss asked about the increased risk of developing cancer, especially colon cancer, with prolonged intake of the product. Orlistat, which is available locally under different brand names, is the only anti-obesity drug approved for over-the-counter sale. When a drug is approved as such, that means there’s no significant risk for people to take it even without a doctor’s prescription. For those who have taken the product, they know that it is a potent inhibitor of the absorption of dietary fats in the intestines. Hence, one needs to go to the bathroom shortly after eating a fatty meal because the fat goes down the gut with reduced absorption and has to be passed out. reported in 2006 that in preclinical studies using experimental rats, orlistat was associated with increased numbers of cells believed to be potential precursors of colon cancer. Therefore, common side effects experienced by those who take it include oily stools, fecal spotting, diarrhea and abdominal pain. They called these cells as “aberrant cryptic foci.” The experts were divided whether or not these are real precursors of colon cancer. I remember a patient telling me this about her experience with orlistat: “I don’t trust it when I fart, because almost always, something goes with it.” Despite the “small accidents” one can have with orlistat, a lot of patients doctors prescribed it to seem not to mind because they get the kind of waistlines they want. US FDA conclusion However, the various clinical trials involving orlistat didn’t show any red flag as to the possibility of developing cancer. Compare levitra to viagra Prednisone can you drink Sildenafil history Cialis generic Orlistat-associated adverse effects and drug interactions a critical review. Filippatos. No significant effect on cancer risk has been reported with orlistat. Orlistat. Read about hernia pain, types of hernias, surgery, surgery complications, and treatment. Learn the signs and symptoms of hernias in men, in women, and in children. A. Oct 18, 2013. Therefore, common side effects experienced by those who take it include. orlistat until a study got published suggesting a risk for colon cancer. A comprehensive review of the safety and effectiveness of this drug. If the drug is not a Do Not Use product, information on adverse effects, drug interactions and how to use the medication are included. Its primary function is preventing the absorption of fats from the human diet by acting as a lipase inhibitor, thereby reducing caloric intake. It is intended for use in conjunction with a healthcare provider-supervised reduced-calorie diet. The effectiveness of orlistat in promoting weight loss is definite but modest. Pooled data from clinical trials suggest that people given orlistat in addition to lifestyle modifications, such as diet and exercise, lose about 2–3 kilograms (4.4–6.6 lb) more than those not taking the drug over the course of a year. Orlistat also modestly reduces blood pressure and appears to prevent the onset of type 2 diabetes, whether from the weight loss itself or other effects. It reduces the incidence of diabetes type II in people who are obese around the same amount that lifestyle changes do. Benefits aside, however, orlistat is notorious for its gastrointestinal side effects (sometimes referred to as treatment effects), which can include steatorrhea (oily, loose stools). Xenical side effects cancer Drugwatch - Trusted Drug & Device Info, Lawsuit & FDA News, Hernia Treatment, Types, Symptoms Pain & Surgery Amoxicillin with milk100mg of sertralineDoes metformin cause diabetesMetoprolol normal dose Find patient medical information for Orlistat Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Orlistat Oral Uses, Side Effects, Interactions, Pictures. -.. Anti-obesity orlistat and colorectal cancer risk Inquirer Business. Orlistat - Wikipedia. Share your medication, wellness, weight loss or disease stories. Search our drug database and user posts on thousands of drugs, diseases and other conditions Search Results for orlistat ALLI, XENICAL. If the drug is not a Do Not Use product, information on adverse effects, drug interactions and how to. incidence of aberrant crypt foci, which are widely believed to be a precursor of colon cancer. Kidney infections or pyelonephritis are varieties and types of infections that involve the urinary tract. Symptoms of kidney infection include abdominal and/or back.