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    Studies in children with burn injuries have demonstrated that propranolol improves metabolism and reduces muscle protein wasting. However, safety and efficacy in adults are less well established than in children. The purpose of this study was to determine safety of propranolol use in adult patients with burn injuries. Medical records were reviewed for burn-injured adults receiving propranolol. Patients between 18 and 65 years old and with ≥20% TBSA burn were included. Fifty-four patients met the criteria with mean age of 37 years and mean burn size of 38% TBSA. Propranolol dosages ranged from 0.1 to 3.8 mg/kg/day, with an average maximum dosage of 0.61 mg/kg/day. Seventy-two percent of patients experienced at least one episode of hypotension and 15% experienced bradycardia. Propranolol hydrochloride Adult Dosing - Epocrates Online Propranolol Oral Route Proper Use - Mayo Clinic The dose of propranolol for migraine prophylaxis. Efficacy of low doses.
     
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