A-Ret Gel 0.1% (Tretinoin) is used as a topical treatment for acne. Some people may also use it for fine wrinkles and its other reported cosmetic benefits in skin aging. It helps to unblock pores on the skin and promote healing and exfoliation on the outer skin layers, while also affecting skin cell growth. Its active ingredient is a topical retinoid similar to vitamin A. A-Ret Gel 0.1% (Tretinoin) is a topical gel that needs to be applied to the affected area in strict compliance with the instructions provided by your doctor. It is also important to ensure that the skin is completely dry, as irritation may occur if the gel is applied to skin that is wet. Allow a minimum of 20 minutes after washing the face before the gel is applied, and avoid washing the treated skin (or applying any cosmetic skincare products to it) for a period of at least one hour after application. Patients are sometimes directed by a doctor to apply the gel once per day, just before bed, or else once every 2 to 3 days. In some cases, a worsening of acne may occur, however, with continued treatment, patients will usually notice an improvement in symptoms. It has been found that topical application of retinoic acid (0.025%) to chronically photodamaged skin regenerated and restored elastic fibers, and that there was a significant positive correlation between the amount of newly regenerated elastic fiber and the wrinkle improvement caused by retinoic acid. Retin-A gel contains the active ingredient tretinoin 0.025%, which is a form of vitamin A used in the treatment of acne. It is not known exactly how tretinoin works, but it is thought to loosen the cells in the surface of the skin. This helps to unblock pores, so that the skin's natural oil producing glands can function normally. 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